QuickView for dihydrofolate reductase;jsessionid=751D0F22D93BA9CC162C1512FB2A95B1;jsessionid=A10841CB22D44A8A8DE1B4D3A6FD7073;jsessionid=AC82069235F4C363ED412000C7F43A86 (gene)
- Gene Symbol:
- Dhfr
Rattus norvegicus - Full name:
- dihydrofolate reductase
- Synonyms:
- Dhfr1, dihydrofolate reductase, Dihydrofolate reductase 1 (active)
- Genomic Location:
- Chr 2: 22607093-22828487
- Description:
-
key component of purine and pyrmidine biosynthesis pathway; NADPH-dependent molecule reduces dihydrofolate to tetrahydrofolate
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
NADP binding | cofactor binding | modified amino acid binding | oxidoreductase activity, acting on the CH-NH group of donors | carboxylic acid binding | nucleic acid binding | mRNA binding | vitamin binding | nucleotide binding | coenzyme binding | catalytic activity | translation regulator activity, nucleic acid binding | sequence-specific mRNA binding | anion binding | folic acid binding | amide binding | translation repressor activity | ion binding | organic cyclic compound binding | dihydrofolic acid binding | translation regulator activity | translation repressor activity, mRNA regulatory element binding | dihydrofolate reductase activity | drug binding | NADPH binding | methotrexate binding | organic acid binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding | RNA binding
GO Biological Process
regulation of cellular response to oxidative stress | regulation of response to oxidative stress | negative regulation of cellular process | pteridine-containing compound biosynthetic process | cell differentiation | nervous system development | response to drug | neurogenesis | polyol metabolic process | generation of neurons | tetrahydrofolate metabolic process | cellular process | oxidoreductase activity, acting on the CH-NH group of donors | regulation of removal of superoxide radicals | dicarboxylic acid metabolic process | neuron development | positive regulation of nitric-oxide synthase activity | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | negative regulation of cellular metabolic process | folic acid-containing compound biosynthetic process | regeneration | regulation of cellular process | regulation of metabolic process | one-carbon metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | folic acid-containing compound metabolic process | tetrahydrobiopterin biosynthetic process | tetrahydrofolate biosynthetic process | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | alcohol metabolic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cofactor metabolic process | cellular biosynthetic process | pteridine-containing compound metabolic process | translation regulator activity, nucleic acid binding | regulation of cellular response to stress | positive regulation of monooxygenase activity | organic hydroxy compound metabolic process | response to nitrogen compound | response to nicotine | regulation of superoxide metabolic process | system development | nitrogen compound metabolic process | coenzyme biosynthetic process | multicellular organism development | regulation of catalytic activity | regulation of nitric-oxide synthase activity | regulation of gene expression | axon development | cellular response to stress | response to axon injury | cofactor biosynthetic process | dihydrofolate metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | response to methotrexate | cellular amide metabolic process | tetrahydrobiopterin metabolic process | biosynthetic process | diol biosynthetic process | neuron projection regeneration | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | folic acid metabolic process | response to toxic substance | translation repressor activity | regulation of cellular metabolic process | regulation of protein metabolic process | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | neuron differentiation | response to organic substance | translation regulator activity | translation repressor activity, mRNA regulatory element binding | vitamin metabolic process | response to wounding | response to antineoplastic agent | dihydrofolate reductase activity | regulation of response to reactive oxygen species | anatomical structure development | cell projection organization | metabolic process | oxidation-reduction process | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | amide biosynthetic process | negative regulation of translation | negative regulation of protein metabolic process | regulation of oxidoreductase activity | response to organic cyclic compound | cell development | organic acid metabolic process | axon regeneration | developmental process | regulation of reactive oxygen species metabolic process | response to organonitrogen compound | cellular modified amino acid metabolic process | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | oxidoreductase activity | regulation of translation | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | intracellular
